Thinking and memory changes in women
Some cancer treatments lower the amount of sex hormones in the body. Low levels of sex hormones can cause problems with concentration, thinking, and memory.
What are the sex hormones?
Hormones are natural substances made by the glands of our hormone system. They are carried around our body in our bloodstream. They act as messengers to carry signals between one part of the body and another.
The main female sex hormones are oestrogen and progesterone.
Hormone therapy to treat breast cancer can work in one of two ways:
- lowering the levels of oestrogen
- blocking the effect of oestrogen on cancer cells
Thinking, memory, and cancer
Our abilities to think, learn, remember, be aware of our surroundings and use our judgment is called cognition.
Sex hormones made by the ovaries are thought to play a role in these processes. Low levels of these hormones may lead to changes in cognition. These changes are also called cognitive changes.
Mild cognitive changes or ‘chemo brain’
Some people notice changes in how they think and remember after hormone therapy. It may not affect you every day. You may forget a word during a sentence or struggle to remember a shopping list.
Doctors call this ‘mild cognitive impairment’. You may hear it described as ‘chemo brain’, or a general ‘fogginess’. It doesn’t only happen after chemotherapy. It can also be a side effect of hormone therapy.
We don’t know exactly what causes cognitive impairment in people with cancer. But research suggests that there might be a number of factors that contribute to it.
These include:
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the cancer itself
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different cancer treatments
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low mood, stress and anxiety
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other factors such as age
For many people, the changes are very subtle and get better after treatment. But if you have them, they can reduce your quality of life.
Researchers are still trying to find out more about how hormone treatment affects memory.
Thought process changes in women
The female hormone oestrogen plays an important part in cognition. It seems to help with remembering words, concentrating, and processing things quickly.
Research into menopause shows that memory and information processing can be affected by changes in hormone levels.
It is likely that treatments that lower oestrogen levels or block the action of oestrogen may affect your ability to think. They may also affect your concentration and ability to remember things. More research is needed to find out who is most at risk of these changes.
Both chemotherapy and hormone therapy for breast cancer can affect oestrogen levels.
Chemotherapy and thought processes
Some chemotherapy drugs can stop the ovaries making oestrogen. This may explain changes in memory and thought processes. Depending on your age, the changes may be temporary or permanent.
Hormone therapy and thought processes
Some studies show that hormone therapies such as tamoxifen and aromatase inhibitors can affect memory. For example, remembering a particular word for something. But we need more research to understand exactly how hormone therapy affects memory and thinking.
Tips to help with changes to thinking and memory
There are things that you can do that may help you cope better with these changes:
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Keep a diary or calendar to help you remember what you need to do each day.
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Write lists of jobs to do, things to buy or where you keep things you use every day.
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Use post-it notes to remind you to do tasks.
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Write down people's names with a description to remember them.
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Repeat information back to people to check understanding.
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Keep your mind active, you could try crosswords, sudoku or puzzles.
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Avoid trying to do too many things at the same time.
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Aim to get a good night's sleep and rest in the day when you need to. Try to avoid becoming overtired.
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Try to exercise each day if possible, this can help you to sleep and lift your mood.
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Follow a balanced diet.
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Stay connected with others such as family, friends and your local community.
Hormone replacement therapy (HRT)
One way to help control hormonal symptoms is to take hormones to replace the ones your body is no longer producing. 
is an effective treatment for many women. But some treatments for breast cancer aim to either stop the body producing sex hormones, or block their action. If you are having these treatments, you can’t unfortunately take HRT.
Doctors don’t routinely recommend that you take HRT if you have a cancer, such as breast cancer. Even if you have finished treatment there is concern that HRT may increase the risk of cancer coming back. Talk to your specialist if you are finding it difficult to cope with your symptoms. They can explain the risks and benefits of HRT and if this is an option for you.
Research
A research study is looking at using a computer training programme to improve cognitive function in people who had stage 1 to 3 breast cancer. The programme has 8 exercises that look at areas, such as:
- attention
- memory
- processing speed
- thinking
Coping
There are things you can do to help you cope and improve your symptoms.
