A study looking at breath samples to detect cancer early (PAN Cancer Early Detection Study)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Bladder cancer

Kidney cancer

Liver cancer

Oesophageal cancer

Pancreatic cancer

Prostate cancer

Stomach cancer

Status:

Closed

Phase:

Other

This study is looking to see if it is possible to analyse breath samples to spot cancer early.

Cancer Research UK supports this study.

More about this trial

It is easier to treat cancer that is diagnosed early. This is because it might be smaller and won’t have spread to other parts of the body. But finding some types of cancer early isn’t easy as there are very few symptoms.

So, researchers are looking for new ways to spot these types of cancer. In this study they are looking at breath samples.

Early research shows that cells inside the body make substances that end up in the blood and are breathed out from the lungs (exhaled). These studies point out that the substances might be different if someone has cancer. The researchers in this study plan to collect and analyse breath samples to see if the exhaled breath can detect cancer. They’ll compare samples from people who have cancer with people who don’t.

The study is open for people who have are having tests at Cambridge University Hospitals NHS Foundation Trust for one of the following types of cancer:

It also included people having tests for the following types of cancer but these groups are now closed:

The aim of the study is to find out if analysing breath sampling can detect patterns of substances that might help spot cancer early.

Please note – you won’t benefit from taking part in this study. But researchers hope it might help people in the future by diagnosing cancer earlier.

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.

Who can take part

This study is for people who are having tests for symptoms that could be one of the following types of cancer:

stomach cancer
cancer of the foodpipe (oesophagus)

It was also for people having tests for the following cancer types but these groups are now closed:

kidney cancer
prostate cancer
bladder cancer
pancreatic cancer
liver cancer

As well as the above, to take part in the study, you must be at least 30 years old.

There are specific entry conditions for each cancer type. The study team will check these to see if you are suitable to take part.

Please note, the researchers are also looking for volunteers who are in general good health. They are also asking people who have cirrhosis of the liver Open a glossary item

to join.

Who can’t take part

You cannot join this study if any of these apply.

Cancer related

You:

can’t give the breath sample
have had experimental treatment as part of a clinical trial in the 28 days before giving the breath sample
have given a tissue sample or had a test called an endoscopy in the 48 hours before doing the breath test
have a type of cancer that doctors aren’t looking at in this study
have cancer that has come back (recurred)
have had any other cancer in the last 2 years apart from basal cell skin cancer , squamous cell skin cancer , CIS of the cervix that was successfully treated at least 1 year before joining this study

Medical conditions

You:

have had a mild infection in the last 2 weeks or a major infection in the last 6 weeks that needed treatment in hospital, for example hepatitis B hepatitis C or tuberculosis
have lung problems such as cystic fibrosis or pneumonitis
have asthma or long term lung disease (chronic obstructive pulmonary disease) and you had treatment in hospital or had to take steroids in the last 6 weeks
have severe kidney problems
have had a stay in hospital for symptoms that aren’t related to the tumour in the last 6 weeks
have HIV with a very low resistance to infection (a severe immune deficiency)
have had lung surgery or a type of lung surgery called VATS or bronchial termoplasty

As well as the main entry conditions, there are specific exclusion conditions for each cancer type. The study team will check these to see if you are suitable to take part.

Trial design

The researchers need 1,100 people to take part. The study is taking place at Addenbrooke's Hospital in Cambridge.

The breath test
The study team will ask you to perform a breathing test. This is quite easy to do. They’ll ask you to wear a special mask over your nose and mouth and breathe normally for a maximum of 12.5 minutes. You might feel a slight wind blowing in your face as you breathe.

During the procedure, a healthcare professional will check your breathing and whether you are comfortable. If you feel uncomfortable during the procedure you are free to stop it and consider continuing afterwards. You will be able to remove the facemask yourself or a healthcare professional will help you.

The mask is attached to small device that collects the sample. The study team will store your breath in 4 small tubes. They will send these to the laboratory to be analysed.

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ReCIVA breath sampler used to collect breath samples

Hospital visits

You have 1 hospital visit to give the breath sample. The research nurse will organise this appointment for you. It takes about 30 minutes.

Before you give the breath sample, the study team:

ask about your medical history
check if you have any symptoms
ask if you take any medication
ask if any of your close family members have ever had cancer
ask if you are a smoker and time since your last cigarette
measure your height and weight
ask what you had had to eat before the test

You then give the breath sample for 12.5 minutes. The study team might ask you to return for an additional three breath samples if you agree to this.

Side effects

There aren’t any side effects of having the breath test. However, having the face mask might feel uncomfortable as it covers the nose and mouth and may feel claustrophobic in a small number of people. The nurse should be able to adjust the straps, and this should help. You are free to stop the breath test at any time if it feels too uncomfortable.