A study looking at the genes in lymphoma cells (MaPLe)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers

High grade lymphoma

Lymphoma

Non-Hodgkin lymphoma

Status:

Closed

Phase:

Other

This study is collecting information about the genes in lymphoma cells. This technique is called molecular profiling. The study is recruiting people with either of the following types of non Hodgkin lymphoma (NHL)

More about this trial

Doctors usually treat NHL with chemotherapy and sometimes a type of biological therapy called a monoclonal antibody. Researchers are looking for ways to improve treatment for lymphoma.

Earlier research has suggested that changes to genes in certain types of lymphoma can encourage the lymphoma to grow. It is possible that new treatments will be able to target these gene changes and may work particularly well in people who have lymphoma with these changes.

The aims of this study are to

Look at gene changes in lymphoma to identify who may be suitable for new targeted treatments
Collect information about these gene changes, the treatment people then have and how well the treatments work
See whether it is possible to carry out molecular profiling of lymphoma in the National Health Service

You do not have any treatment as a result of taking part in this study. The researchers will carry out molecular profiling on your lymphoma cells and this information is passed on to your doctor who will discuss the results with you. This may play a part in which treatments your doctors recommend for you in the future.

Who can enter

You may be able to join this study if all of the following apply

You are having tests for, or have a diagnosis of, either diffuse large B cell lymphoma or grade 3b follicular lymphoma
Your doctor thinks that you may be suitable for targeted therapy either now or in the future
There is a sample (biopsy ) of your lymphoma that is available for the study team to look at (this may have been taken either when you were first diagnosed or if your lymphoma has come back)

Trial design

This study will recruit over 3,000 people. The study team will send a sample (biopsy) of your lymphoma and a blood sample to a laboratory in Leeds for molecular profiling. This can take about 4 weeks to carry out.

The results of your molecular profiling are sent back to your doctor and they will discuss these results and what they may mean for you.

Your doctor may use some of these results to help them decide on treatment in the future. The study team will collect information about the treatment you have and how your lymphoma responds to see how this relates to any gene changes.

The researchers will ask your permission to keep some of your tissue sample in storage to use in future research. This is unlikely to benefit you, but it may be used to learn more about lymphoma. If you don’t want to give these samples for future research, you don’t have to. You can still take part in the main study.