A study to collect tissue and blood samples from people in clinical trials (CALIBRATE)
Cancer type:
Status:
Phase:
This study is collecting cancer tissue and blood samples from people who are taking part in a cancer clinical trial. Researchers want to see if they can find a new way to see how well cancer treatment works.
More about this trial
Doctors take a small piece of cancer tissue (
) to find out more about the cancer cells. One thing they look at is how cancer may respond to treatment. Circulating tumour DNAs (ctDNAs) are small pieces of cancer cell that are in the blood stream. This DNA is released into the bloodstream by dying cancer cells. The researchers think looking at ctDNAs can also show how well the cancer is responding to treatment.
In this study they will take blood samples before, during and after treatment to see if they can see a change in the ctDNA. Changes in the ctDNA might be able to tell them whether treatment is working or not.
The team also want to:
- find how safe it is to take tissue samples from people who are having experimental treatment as part of a clinical trial
- ask you your opinion about taking research samples in clinical trials
Who can enter
You may be able to join this study if all of the following apply. You
- Have cancer and are going to the Addenbrooke’s hospital in Cambridge
- Are thinking of taking part in a clinical trial that is using an experimental drug
- Are at least 18 years old
You cannot join this study if you have a medical or mental health condition that the study team think could affect you taking part.
Trial design
The study team need 200 people to join.
The study team will take some extra blood samples from you before, during and after your treatment as part of the clinical trial.
They might ask you to do give a blood sample by pricking your finger and putting a drop of blood on a piece of card. You can do this at home. The team will give you instructions on how to do it. You don't have to agree to this. You can still take part in the main study.
They will ask for a sample of your cancer that was removed when you had surgery or a .
The team will ask if you are willing to have biopsies done during the study. This is so they can obtain fresh samples of your cancer tissue. They will also ask if you are willing to fill in 2 questionnaires. The questionnaires will ask you your opinions about research samples taken as part of a clinical trial. You can agree to do both, only one or neither. Either way you can still take part in the main study.
Hospital visits
The research team will take the blood samples when you have your routine bloods done for the clinical trial.
If you agree to have the biopsies done, they will try to arrange them at the same time as your routine hospital appointments. The trial team can let you know what having a biopsy will involve.
Side effects
You may have some discomfort, bruising and slight bleeding from the blood samples.
Taking a biopsy is a safe procedure. You may have some discomfort, bruising and slight bleeding.
Location
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Chief Investigator
Dr Richard Baird
Supported by
Addenbrookes Charitable Trust (ACT)
AstraZeneca
Cambridge Clinical Trials Unit - Cancer Theme
Cambridge University Hospitals NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Cambridge
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
