A study using ultrasound scans to diagnose prostate cancer (CADMUS)
Cancer type:
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Phase:
This study looked at whether ultrasound scans were as good as MRI scans for diagnosing prostate cancer. It was for men who were having tests for prostate cancer.
The study was open for people to join between 2016 and 2019. The team published the results in 2022.
More about this trial
When this study was done, doctors often used MRI scans to look for any areas in the prostate that might be cancer. They then take a tissue sample (biopsy) from those areas to look for cancer cells.
Ultrasound scans are cheaper and quicker than MRI scans. Researchers hoped that a multiparametric ultrasound scan would be as good as a multiparametric MRI scan. Multiparametric means combining different scanning techniques in one scan. This gives a more detailed and accurate picture.
People in this study had an MRI scan and an ultrasound scan. If either of the scans showed signs of possible prostate cancer, they had a biopsy.
The study team compared the results of the MRI scan, the ultrasound scan and the biopsy.
The main aim of this study was to see if ultrasound scans are as good as MRI scans for diagnosing prostate cancer.
Summary of results
Study design
This study was for men having tests for possible prostate cancer. This was usually because they had an abnormal PSA blood test or prostate examination.
They had an MRI scan and an ultrasound scan. The research team looked at how many people were likely to have prostate cancer based on the scan results.
Results
A total of 306 people had both an MRI scan and an ultrasound scan.
The research team looked at how many scans showed possible prostate cancer. They found it was:
- 238 MRI scans (78%)
- 272 ultrasound scans (89%)
Following a biopsy, 133 men were diagnosed with prostate cancer. Some of these were very early stage and didn’t need treatment. But 83 men were diagnosed with prostate cancer that needed treatment (clinically significant cancer).
Of these:
- 60 were detected by both the MRI scan and the ultrasound scan (72%)
- 6 were detected by the ultrasound scan but not the MRI scan (7%)
- 17 were detected by the MRI scan but not the ultrasound scan (20%)
More people were referred for a biopsy because of their ultrasound scan results. But fewer people were diagnosed with clinically significant prostate cancer from that.
Conclusion
The research team concluded that the results were similar for the two types of scan. They suggest that an ultrasound scan could be used if an MRI scan is not available, or the person is not able to have one.
They concluded that doing both an ultrasound scan and an MRI scan is the most accurate way to detect prostate cancer.
More detailed information
There is more information about this research in the reference below.
Please note, this article is not in plain English. It has been written for health care professionals and researchers.
Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study
A Grey and others
Lancet Oncology, 2022. Volume 23, issue 3, pages 428 to 438.
Where this information comes from
We have based this summary on the information in the article above. This has been reviewed by independent specialists (
) and published in a medical journal. We have not analysed the data ourselves.
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How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Chief Investigator
Professor Hashim Uddin Ahmed
Supported by
The Jon Moulton Charity Trust
Prostate Cancer UK
NIHR Clinical Research Network: Cancer
University College London (UCL)
Imperial College London
Barts Charity
Bracco S.p.A
Hitachi Medical Systems UK Ltd
BK ultrasound systems
GE Healthcare
Esoate
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
