A study looking at the genetic causes of chronic lymphocytic leukaemia

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers

Chronic leukaemia

Chronic lymphocytic leukaemia (CLL)

Leukaemia

Status:

Closed

Phase:

Other

This study is trying to find out more about the causes of chronic lymphocytic leukaemia and to identify genes that may be important in the development of this cancer.

There are a few known risk factors for chronic lymphocytic leukaemia. We know that CLL can run in families, but so far we haven’t found any specific gene changes that are linked to CLL.

In this study, the researchers will look at the genes of a large number of people who have chronic lymphocytic leukaemia (CLL). They will also ask them about their family history.

The aim of the study is to identify genes that could increase the risk of CLL.

Who can enter

You can enter this trial if you have chronic lymphocytic leukaemia (CLL).

Trial design

This study will recruit 5,000 people in the UK with chronic lymphocytic leukaemia (CLL). When you go to see your doctors, they may ask you if you are interested in taking part in the study.

If you agree to take part, you will be asked to fill in a questionnaire. It will ask about your relatives and whether they have had any type of cancer.

You will be asked to give a small sample of blood. You may give this at your GP surgery or hospital.

The DNA from your sample will be safely stored and only used in this study. The researchers will look at the DNA to try and find genes that may increase the risk of developing CLL. The DNA sample is taken for the purpose of this study only.

The researchers may want to contact other members of your family. But they will ask you before they do.